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Nutrition: Zinc
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Total 18496 results found since Jan 2013.
Long-term zinc deprivation accelerates rat vascular smooth muscle cell proliferation involving the down-regulation of JNK1/2 expression in MAPK signaling
Conclusion: The results showed that chronic zinc deprivation accelerated VSMC proliferation, perhaps due to down-regulation of MAPK-JNK signaling, and that the anti-cell proliferative role of zinc is VSMC-specific. The findings suggested that zinc may have anti-VSMC proliferative properties in atherosclerosis.Highlights: ► Chronic (long-term) Zn deprivation accelerated VSMC proliferation. ► Zn deprivation-induced VSMC proliferation was associated with decreased JNK levels. ► Anti-proliferative effect of Zn was found to be VSMC-specific.
Source: Atherosclerosis - March 6, 2013 Category: Cardiology Authors: Ethel H. Alcantara, Mee Young Shin, Jörg Feldmann, Graeme F. Nixon, John H. Beattie, In Sook Kwun Tags: Vascular Biology, Hemostasis, Oxidative Stress Source Type: research
Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation.
Conclusions- This study gives us a direct in vivo evidence of GATA-6 cell lineage-specific regulation of PDGF-B and CCN-5 on VSMC phenotypic state, proliferation and migration contributing to neointimal formation, which advances our understanding of in vivo neointimal hyperplasia, meanwhile also provides opportunities for future therapeutic interventions.
PMID: 30943773 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 3, 2019 Category: Cardiology Authors: Zhuang T, Liu J, Chen X, Pi J, Kuang Y, Wang Y, Tomlinson B, Chan P, Zhang Q, Li Y, Yu Z, Zheng X, Reilly M, Morrisey E, Zhang L, Liu Z, Zhang Y Tags: Arterioscler Thromb Vasc Biol Source Type: research
From the Cover: Zinc Deficiency Worsens and Supplementation Prevents High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and Pathological Remodeling
Obesity has become a common public health problem in the world and raises the risk of various cardiovascular diseases. Zinc is essential for multiple organs in terms of normal structure and function. The present study investigated the effects of high fat diet (HFD) induced obesity on the aorta in mice, and evaluated whether it can be affected by zinc deficiency or supplementation. Four-week-old male C57BL/6J mice were fed HFD with varied amounts of zinc (deficiency, adequate and supplementation) for 3 and 6 months. Results showed that HFD feeding induced a time-dependent aortic remodeling, demonstrated by increased vessel ...
Source: Toxicological Sciences - August 30, 2016 Category: Toxicology Authors: Chen, J., Wang, S., Luo, M., Zhang, Z., Dai, X., Kong, M., Cai, L., Wang, Y., Shi, B., Tan, Y. Tags: Effects of Zinc Levels on Vascular Inflammation and Oxidative Stress Source Type: research
Marginal dietary zinc deficiency in vivo induces vascular smooth muscle cell apoptosis in large arteries
Conclusion
In conclusion, a marginally zinc-deficient diet is pro-apoptotic for VSMCs and this may contribute to cardiovascular disease.
Source: Cardiovascular Research - July 22, 2013 Category: Cardiology Authors: Allen-Redpath, K., Ou, O., Beattie, J. H., Kwun, I.-S., Feldmann, J., Nixon, G. F. Tags: Vascular biology Source Type: research
Biochemical markers and anthropometric profile of children enrolled in public daycare centers
CONCLUSION: Therefore, since the influence of the family is an important predictor of overweight and its future outcomes related to nutritional deficiencies and inadequate dietary intake, educational interventions are vital as a way to pave the path to prevention.PMID:34774468 | DOI:10.1016/j.jped.2021.09.006
Source: Jornal de Pediatria - November 14, 2021 Category: Pediatrics Authors: Luiz Felipe de Paiva Louren ção Nara Cristina de Paula Maria Ang élica Cardoso Paula Ribeiro Santos Izabela Regina Cardoso de Oliveira Fernando Luiz Affonso Fonseca Glaucia Luciano da Veiga Beatriz da Costa Aguiar Alves Miriam Monteiro de Castro Gracia Source Type: research
Blood tests and use of nutritional supplements in a cohort of Brazilian children with trisomy 21
CONCLUSIONS: Nutritional supplements (mainly vitamins, minerals, omega-3 and antioxidants) are frequently used by Brazilian T21 children independently of professional counseling and/or supervision and should be a question to be raised during the clinical anamnesis since some of them may impact medical conduct. Moreover, many blood tests are altered in this population and clinicians should be aware of them in order to warrant an appropriate screening and the implementation of risk management measures as soon as possible and improve the general health of these persons.PMID:37353208 | DOI:10.1016/j.jped.2023.05.009
Source: Jornal de Pediatria - June 23, 2023 Category: Pediatrics Authors: Andrea M M Miyasaki Julia M Radigonda Rodrigo M Klein Estef ânia G Moreira Source Type: research
Adaptation of Vascular Smooth Muscle Cell to Degradable Metal Stent Implantation
ACS Biomater Sci Eng. 2023 Jun 26. doi: 10.1021/acsbiomaterials.3c00637. Online ahead of print.ABSTRACTIron-, magnesium-, or zinc-based metal vessel stents support vessel expansion at the period early after implantation and degrade away after vascular reconstruction, eliminating the side effects due to the long stay of stent implants in the body and the risks of restenosis and neoatherosclerosis. However, emerging evidence has indicated that their degradation alters the vascular microenvironment and induces adaptive responses of surrounding vessel cells, especially vascular smooth muscle cells (VSMCs). VSMCs are highly fle...
Source: Atherosclerosis - June 26, 2023 Category: Cardiology Authors: Meichun Wu Min Xun Yuping Chen Source Type: research
Crosstalk of copper and zinc in the pathogenesis of vascular dementia
J Clin Biochem Nutr. 2022 Jul;71(1):7-15. doi: 10.3164/jcbn.22-40. Epub 2022 Jul 1.ABSTRACTCopper and zinc are essential for normal brain functions. Both are localized in presynaptic vesicles and are secreted into synaptic clefts during neuronal excitation. Despite their significance, excesses of copper and zinc are neurotoxic. In particular, excess zinc after transient global ischemia plays a central role in the ischemia-induced neurodegeneration and pathogenesis of vascular type senile dementia. We previously found that sub-lethal concentrations of copper remarkably exacerbated zinc-induced neurotoxicity, and we investig...
Source: Clinical Biochemistry - July 29, 2022 Category: Biochemistry Authors: Masahiro Kawahara Ken-Ichiro Tanaka Midori Kato-Negishi Source Type: research
